Calming Chews
180g / 6.35oz / 60 chews
Promotes relaxation
Reduces hyperactivity
Regulates cortisol
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Relora® is used under license.
Premium, Ethically-Sourced Ingredients
Made in USA
GMP Certified
In line with FDA CVM Guidelines
90 Day Satisfaction Guarantee
Premium, Ethically-Sourced Ingredients
Made in USA
GMP Certified
In line with FDA CVM Guidelines
90 Day Satisfaction Guarantee
Dr. Meghan Barrett
DVM, cVMA, CCRT, CVFT, FFCP, CCVN
Dr. Tiffany Ruiz-Da Silva
VMD, cVMA
Smudge
Wuffes Calming Chew Superfan
Charlie
Wuffes Calming Chew Superfan
Dave
Wuffes Calming Chew Superfan
Here's a crazy statistic for you – almost 50% of dogs suffer from fear and anxiety.*
Things like a simple doorbell ringing, car ride or trip to vet can feel like a complete sensory overload.
So, how can you tell if your pup is stressed out? See if any of the signs below check out:
Barking or Whining
Lip Licking or Tail Chasing
Pacing or Restlessness
Destructive Behaviour
Frequent Peeing Indoors
Hiding or Attempting to Escape
Ears Pinned Back or Tail Tucked
Trembling or Shaking
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Some highly intelligent and sensitive breeds are especially prone to these behaviors:
Some highly intelligent and sensitive breeds are especially prone to these behaviors:Border Collies • German Shepherds • Australian Shepherds • Vizslas • Italian Greyhounds • Chihuahuas • Toy Poodles • Shetland Sheepdogs • Weimaraners
*Source: Texas A&M College of Veterinary Medicine.
Daily Support, Made Simple
Formulated with active ingredients at meaningful amounts, every Wuffes chew is designed to deliver real benefits, not empty promises.
Directions for Use
0-35 lbs
1 soft chew daily
36-65 lbs
2 soft chews daily
66-100 lbs
3 soft chews daily
101-120 lbs
4 soft chews daily
Over 121 lbs
5 soft chews daily
We recommend giving supplements as part of their normal routine
What Are They Stressed About?
Everyday stresses?
For everyday stresses, take the chews daily.
Specific stressful situation?
For stressful situations you know are coming up, take chews 3-4 weeks before.
What You'll Start to See
Our chews are scientifically formulated with clinically tested ingredients to bring out the best in your pup.
Promotes relaxation, without sedation
Supports emotional balance and stress regulation
Helps promote calm behaviour
Maintains normal cortisol levels
In a Sea of Products, Why Trust Us?
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EVERYONE ELSE 
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COST PER CHEW |
$0.41 |
$0.44 – $1+ |
TOTAL ACTIVE INGREDIENTS PER CHEW |
💪🏻 |
👎 |
CLINICALLY STUDIED AMOUNT |
🧪 |
❌ |
HIGHLY CONCENTRATED |
✅ |
❌ |
VETERINARIAN APPROVED |
✅ |
❌ |
NASC APPROVED 
|
✅ |
🤷🏼 |
MADE IN USA |
✅ |
💩 |
MONEY-BACK GUARANTEE |
✅ |
🤷🏼 |
The ingredients in our Calming Chews have been scrutinized in thousands of studies, and are meticulously selected for their combined effect to reduce stress and promote calm.
Relora®
Featured In:
Featured In:
Featured In:
Featured In:
The Research
- Demonstrated to help dogs stay calm during noise-related stressful events, such as thunderstorms and fireworks (DePorter et al., 2002)
- Supports overall behavioral relaxation and improved mood during times of stress (DePorter et al., 2002)
- Shown to help maintain cortisol balance and calm behavior during times of occasional stress (Garrison et al., 2006)
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
- Chamomile Extract – 50mg
- GABA (Gamma-Aminobutyric Acid) – 35mg
- L-Tryptophan – 35mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pollock Oil, Pork Spray Dried Liver, Rosemary Extract, Sunflower Lecithin, Tapioca Starch.
Check out our Ingredients Glossary for more info.
Relora® is used under license.
The Research
- Shown to support a healthy stress response and help maintain normal cortisol patterns associated with stress (Keefe et al., 2018; Saadatmand et al., 2024).
- Associated with promoting relaxation, emotional balance, and calm behavior during periods of occasional stress (Saadatmand et al., 2024; Alvarado-García et al., 2024).
- Research suggests chamomile supports normal neurological function and relaxation pathways through its natural bioactive compounds, including apigenin (Jabri et al., 2022; El Mihyaoui et al., 2022).
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
- Chamomile Extract – 50mg
- GABA (Gamma-Aminobutyric Acid) – 35mg
- L-Tryptophan – 35mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pollock Oil, Pork Spray Dried Liver, Rosemary Extract, Sunflower Lecithin, Tapioca Starch.
Check out our Ingredients Glossary for more info.
The Research
- Demonstrated to help reduce occasional vocalization associated with stress, such as whining and barking (Inagawa et al., 2005).
- Shown to support calm behavior in dogs when left alone (Inagawa et al., 2005).
- Dietary supplementation of GABA demonstrated to support neurotransmitter balance involved in stress and relaxation (Jiang et al., 2025).
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
- Chamomile Extract – 50mg
- GABA (Gamma-Aminobutyric Acid) – 35mg
- L-Tryptophan – 35mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pollock Oil, Pork Spray Dried Liver, Rosemary Extract, Sunflower Lecithin, Tapioca Starch.
Check out our Ingredients Glossary for more info.
The Research
- Shown to support a normal inflammatory response and promote overall physiological balance associated with well-being (Zhu et al., 2019).
- Supplementation has been associated with supporting calm behavior and balanced activity levels in dogs during periods of environmental stress (Sofyan, 2024).
- Research suggests L-tryptophan helps maintain normal serotonin pathways involved in mood and stress response (Höglund et al., 2017; Yue et al., 2017).
- Supports healthy coping behavior and emotional balance during routine stressors (Höglund et al., 2017).
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
- Chamomile Extract – 50mg
- GABA (Gamma-Aminobutyric Acid) – 35mg
- L-Tryptophan – 35mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pollock Oil, Pork Spray Dried Liver, Rosemary Extract, Sunflower Lecithin, Tapioca Starch.
Check out our Ingredients Glossary for more info.
Quality You Don’t Have to Question
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With Globally Sourced Ingredients
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Batch Tested
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No Artificial Colors or Flavors
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GMO, Hormone & Antibiotic free
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GMP/SQF Certified
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In line with FDA CVM Guidelines
Proudly NASC-Certified
Tested for quality
All supplements are rigorously tested and audited
Trusted ingredients
Only high-quality, traceable ingredients
Manufactured safely
We follow Good Manufacturing Practices for consistency.
Trust in every tub
The NASC Seal guarantees uncompromised quality
Clear and transparent
Our labels give you full transparency about ingredients.
Scientifically formulated
Formulated using the latest nutritional science for maximum efficacy
These reviews are for informational purposes only. The information is not a substitute for expert veterinary care. Reviews are written by actual customers and represent their own observations. These observations are not guaranteed, are not medically substantiated, and may not be typical for other pets. When necessary, reviews will be replied to privately.
- NPNorma P.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 7-9 years oldPet Size 20-40lbsRated 5 out of 5 stars1 month agoPups approve!
My picky pups enjoy these chews and do not turn their nose up at them! We take them at bedtime and it helps us have a calm sleep routine. Would recommend!
- NPNancy P.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 1-3 years oldPet Size 40-60lbsRated 5 out of 5 stars1 month agoThese chews are effective and apparently taste good too!
We were sent a container of these chews for a dog that we sadly lost unexpectedly to cancer and bloat. She was a dreamboat and we adored her. We accepted the chews because we have 10 dogs and knew they would be useful...they were!
We got 2 young German Shepherd/Husky mix fosters, Momma and Son, and they needed grooming badly. I gave them chews based on their weight before their grooming appointment and the groomer said they were the "best Husky mixes she's ever had!" I took that as a sign that the chews did their job! Both of them gobbled the chews up, so the taste must be pretty yummy.
We have been using Wuffes products for years and I stand by their effectiveness and quality.
- MSMarc S.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 10-12 years oldPet Size Over 100lbsRated 5 out of 5 stars1 month agoLarge Senior Dog
My 150 LB dog, Camo is not very active in his later stage, but at times he would tend to seem a bit anxious about seeing being alone when I would leave for work. The effects from the calming chews seem to take the edge off and put him in a more relaxed content mood. I think that I additionally see him being a little happier. I do not give him the chews daily, only occasionally. He had never been a dog that gets wound up with noses or lots of activity outside, so I cannot attest to having a sedative effect to address a hyper sensitive temperament. It's reassuring to be able to give a product with natural ingredients, as opposed to prescribed medication. Camo has been on Wuffes joint supplement for years and I truly believe that they have provided relief and added longevity to his big boned, sore joint life. I certainly recommend this product!
- KLKim L.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 4-6 years oldPet Size 60-80lbsRated 5 out of 5 stars1 month agoAmazing!!
Our beautiful girl was previously abused. She was so skittish over the smallest noises. We have been giving them periodically to her. She's more relaxed. Thank you so much for the opportunity to try these.
- KKKasey K.Verified BuyerReviewingCalming ChewsI recommend this productPet Age 7-9 years oldPet Size 60-80lbsRated 5 out of 5 stars1 month ago10 Paws Up!!!
While two of my dogs experience anxiety, all five of my dogs liked the taste and thought that they were treats! They were easy to break apart of needed for smaller dogsFor my anxious dogs, it is a gentle, non-sedating calming support that definitely took the edge off. I noticed a difference in their behavior about two weeks into a daily dosage routine. Wuffes Calming Chews were much more effective other brands that I have tried in the past. I would definitely recommend them and continue my subscription!
How many chews should I give my dog?
Use your pet’s weight to follow the directions for use below.
How can I benefit my dog?
Our expertly formulated chews contain four clinically proven ingredients to help your pup feel more relaxed and balanced – without the strong sedatives. Whether it’s thunder, travel, new environments, new people or spending time alone, it’s about time they felt less nervous, stressed and out of it. Benefits include:
- Promotes relaxation, without sedation
- Supports emotional balance and stress regulation
- Helps promote calm behavior
- Maintains normal cortisol levels
- Supports healthy neurotransmitter activity (serotonin, GABA, dopamine)
Our chews are ideal for dogs who struggle with:
- Separation anxiety
- Noise sensitivity (including fireworks or thunderstorms)
- Travel or unfamiliar environments
- General restlessness, pacing, or hyperalertness
How should the chews be stored?
Our Calming Chews for dogs are shelf stable unopened for 2 years. You can store them in your cupboard at room temperature for up to 3 months. If you intend to use the chews after 3 months, we recommend storing your chews in the fridge to preserve their freshness.
Do the chews contain any allergens?
In order to look out for as many pups as possible, we formulated our chews with allergies in mind. If you or your pet is particularly sensitive, please note that Calming Chews contain Pork Liver, Pollock Oil and Brewer’s Yeast (gluten).
Can my dog overdose on these chews?
Our chews are formulated with safe, well tolerated ingredients. However, exceeding the recommended dose may cause mild digestive upset. Always follow the directions for use and consult your vet before starting any new supplement. If your pet accidentally consumes more than the recommended dose, monitor for symptoms and consult your veterinarian if concerns arise.
What happens if my dog eats these chews all at once?
If your dog eats too many all at once, you can expect your dog to have minor issues, such as gastrointestinal discomfort – like gas and bloating. These symptoms should subside in 2-3 days. If your dog has persistent vomiting and diarrhea, please consult your veterinarian. Your vet will make recommendations based on your pet’s age, size and pre-existing conditions.
Where are these chews made?
Our chews are proudly made in the USA from globally sourced ingredients.
How do I know if my dog needs a calming supplement?
Every dog gets a little anxious now and then, but if your pup regularly seems unsettled, it could be a sign they need some extra support. Our Calming Chews are a gentle way to help ease those everyday stresses. Here are some common signs your dog may benefit from our chews:
- Pacing or struggling to relax
- Whining, barking, or howling for no clear reason
- Easily startled or always on alert
- Shaking or trembling (not from cold)
- Panting even when calm or cool
- Hiding or trying to escape certain situations
- Chewing, digging, or scratching when left alone
- Changes in appetite – eating much more or much less
- Repetitive behaviors like constant licking or tail chasing
- Accidents indoors despite being housetrained
If you’re noticing any of these, it might be time to talk with your vet about adding a calming supplement to your dog’s routine. Many dog parents find that even small changes can make a big difference in their dog’s comfort and behavior.
Can these chews be used with other supplements or prescription medication?
Yes. These chews can generally be used alongside other supplements or medications. However, we recommend consulting your veterinarian if your dog has pre-existing conditions or is taking prescription drugs before starting any new supplement.
How old does my dog have to be to eat these chews?
These chews are suitable for pets over 6 months of age.
My dog has a health condition, are these chews suitable for them?
Our chews are formulated with gentle, well tolerated ingredients and are typically safe for dogs with common health conditions. Still, we recommend checking with your veterinarian before use, particularly if your dog has a chronic illness or is on medication.
Are these chews safe for cats?
These chews are specifically formulated for dogs and have not been tested for safety or efficacy in cats.
Cats have different metabolic and neurological responses to supplements, particularly to ingredients like GABA (Gamma-Aminobutyric Acid), Chamomile, and Relora®. We do not recommend giving this product to cats unless specifically directed and approved by a veterinarian. Relora® is used under license.
Where is it made?
Our products are proudly made in the USA from globally sourced ingredients.
Do pets need joint supplements?
Joint supplements are important because they help support and maintain joint health, particularly in aging dogs or those with specific joint-related issues. They can also be beneficial for younger pups, especially larger dogs and breeds that are prone to joint issues.
Can it be used with other supplements or prescription medication?
Absolutely. As long as you follow our directions for use, our joint chews should not interfere with other supplements or prescription medications.
Where can I find my account?
All you have to do is click on the user icon on the top right of the page - right next to the shopping cart.
Where are your products made?
We’re proud to say all of our products are made in the USA with domestically and globally sourced ingredients.
How long do orders take to ship?
All orders placed before noon are shipped on the same day, while all other orders will ship within 1 business day. Not to worry, we won’t keep you waiting!
How do I return an item?
If you’re not satisfied with your purchase, please email hello@wuffes.com and our customer service will be happy to help.
Where are your products shipped from?
All our products are made in the USA and shipped from our warehouse in Denver, Colorado.
Can I give Wuffes supplements to a pregnant dog?
Our products haven’t been tested on pregnant or lactating dogs so we recommend speaking to your vet beforehand.
We’re so sure you’ll love our products, we offer a 90-day money back guarantee on all our edible supplements.
